Una receta saludable de chocolate:
Se cortan trocitos de piña, cerezas, bolitas de melón, fresas etc. se derrite chocolate sin azucar y con un palito se bañan las frutas y se ponen en un papel donde no se peguen se meten a la refrigeradora y cuando están duritos están listos los bombones.
Tenga paciencia con la barriga que lleva años desarrollarla, así que poco a poco va a ir bajando. El anís ayuda porque desinflama.
ESPINACAS - Tienen vit. a, c b, b9, hierro, calcio, es regeneradora de glóbulos rojos, bajo contenido de carbohidratos, proteinas pocas pero mas que otros vegetales, ayuda a la digestión, alivia el estreñimiento, la vista, hipertensión, irritación de la piel, antioxidantes, sus hojas tienen ácido fólico en abundancia, ideal para
formar sangre. La vit. c se pierde al cocinarlas, pero se puede hacer un licuado o picar las hojas y comérselas con la ensalada. (Tomado de La Tribuna 8 jun 09 pág. 89).
DURAZNO O MELOCOTON - Tienen vit a, c, e, ayudan a prevenir el envejecimiento precoz y la degeneración de los tejidos, fortalece el sistema inmunológico, símbolo de la longevidad y la inmortalidad en la
filosofía Taoista (china). Elimina los radicales libres, evita enfermedades degenerativas como cancer, alzheimer o cataratas. Tiene minerales como el potasio (regula la tensión arterial), fósforo (para el sistema nervioso y el cerebro) magnesio que previene el cansancio, ansiedad, estrés. Ayuda a la digestión, al hígado porque incrementa la producción de bilis y la digestión de las grasas. Favorece la disolución de ¨piedras renales¨, beneficia la actividad intestinal y combate el estreñimiento.
Una salsa rápida para pastas: Se sofríe ajo bien picadito, sin que se queme se le agrega tomate, orégano, perejil, y otras hierbas aromáticas y se mezcla con la pasta, es baja en grasa porque solo lleva el poquito de aceite de oliva en que se sofríen ajo, tomates y hierbas y sabe muy bien. No olvidar comer pescado por el omega 3.
sites.google.com/site/economiasiglo21/
A SHOCKING VIDEO ABOUT HUMAN CRUELTY
Se cortan trocitos de piña, cerezas, bolitas de melón, fresas etc. se derrite chocolate sin azucar y con un palito se bañan las frutas y se ponen en un papel donde no se peguen se meten a la refrigeradora y cuando están duritos están listos los bombones.
Tenga paciencia con la barriga que lleva años desarrollarla, así que poco a poco va a ir bajando. El anís ayuda porque desinflama.
ESPINACAS - Tienen vit. a, c b, b9, hierro, calcio, es regeneradora de glóbulos rojos, bajo contenido de carbohidratos, proteinas pocas pero mas que otros vegetales, ayuda a la digestión, alivia el estreñimiento, la vista, hipertensión, irritación de la piel, antioxidantes, sus hojas tienen ácido fólico en abundancia, ideal para
formar sangre. La vit. c se pierde al cocinarlas, pero se puede hacer un licuado o picar las hojas y comérselas con la ensalada. (Tomado de La Tribuna 8 jun 09 pág. 89).
DURAZNO O MELOCOTON - Tienen vit a, c, e, ayudan a prevenir el envejecimiento precoz y la degeneración de los tejidos, fortalece el sistema inmunológico, símbolo de la longevidad y la inmortalidad en la
filosofía Taoista (china). Elimina los radicales libres, evita enfermedades degenerativas como cancer, alzheimer o cataratas. Tiene minerales como el potasio (regula la tensión arterial), fósforo (para el sistema nervioso y el cerebro) magnesio que previene el cansancio, ansiedad, estrés. Ayuda a la digestión, al hígado porque incrementa la producción de bilis y la digestión de las grasas. Favorece la disolución de ¨piedras renales¨, beneficia la actividad intestinal y combate el estreñimiento.
Una salsa rápida para pastas: Se sofríe ajo bien picadito, sin que se queme se le agrega tomate, orégano, perejil, y otras hierbas aromáticas y se mezcla con la pasta, es baja en grasa porque solo lleva el poquito de aceite de oliva en que se sofríen ajo, tomates y hierbas y sabe muy bien. No olvidar comer pescado por el omega 3.
sites.google.com/site/economiasiglo21/
A SHOCKING VIDEO ABOUT HUMAN CRUELTY
Miré un programa de la tve española que también tiene su página http://www.sabervivir.es
Si se comen grandes cantidades, se dispara una hormona que nos hace comer cada vez más porciones más grandes. Si al organismo solo se le da una cosa, se alteran todas las otras cosas. Hay que comer poco, bueno y saludable.
Dietas excesivamente restrictivas como las de 500 o 600 calorías son una agresión para el organismo y se pierde músculo para conseguir la glucosa que usa el cerebro. Después se come mucho más para compensar y se vuelve a engordar.
Los hidratos de carbono no se pueden sustituir por grasas porque sube la tensión arterial y hay probabilidades de infarto, además se produce depresión y se incrementa el colesterol.
Ahora es peligroso seguir dietas porque el potencial de gente que quiere adelgazar es mucha y hay negocios que no son éticos. Lo que engorda es lo que comemos de más y que no necesitamos. Hay una dieta en que no se mezclan hidratos de carbono, proteinas y grasas. Hay dietas desiquilibradas sin hidratos de carbono que afectan la salud. Dietas de 4 días en las que solo se come una cosa, eso nos engorda más porque es una agresión muy fuerte al organismo que después el mismo organismo tiene que compensar.
La anarquía de los horarios afecta porque no sabemos cuánto estamos comiendo. Además se descontrola el mecanismo del hambre. Hay que tener horarios y el hambre volverá. Si se come mientras se ve tele se desconecta el mecanismo de la saciedad, y no sabemos cuándo dejar de comer.
Hay una dieta que siguen algunos artistas (dieta de la zona) que es 40% carbohidratos, 30% proteínas y 30% grasa. El problema es que una dieta normal solo debe incluir 15% de proteínas y comiendo 30% de proteínas se come más grasa saturada. Además todo depende del % de grasa corporal y la actividad física. A una señora le vendieron en su casa un polvo para adelgazar y terminó en el hospital con problemas cardíacos.
QUIERE DIVERTIRSE? VEA CHISTES MEDICOS AQUI: http://tipsparalamujer.googlepages.c om/mujer.pps
Si se comen grandes cantidades, se dispara una hormona que nos hace comer cada vez más porciones más grandes. Si al organismo solo se le da una cosa, se alteran todas las otras cosas. Hay que comer poco, bueno y saludable.
Dietas excesivamente restrictivas como las de 500 o 600 calorías son una agresión para el organismo y se pierde músculo para conseguir la glucosa que usa el cerebro. Después se come mucho más para compensar y se vuelve a engordar.
Los hidratos de carbono no se pueden sustituir por grasas porque sube la tensión arterial y hay probabilidades de infarto, además se produce depresión y se incrementa el colesterol.
Ahora es peligroso seguir dietas porque el potencial de gente que quiere adelgazar es mucha y hay negocios que no son éticos. Lo que engorda es lo que comemos de más y que no necesitamos. Hay una dieta en que no se mezclan hidratos de carbono, proteinas y grasas. Hay dietas desiquilibradas sin hidratos de carbono que afectan la salud. Dietas de 4 días en las que solo se come una cosa, eso nos engorda más porque es una agresión muy fuerte al organismo que después el mismo organismo tiene que compensar.
La anarquía de los horarios afecta porque no sabemos cuánto estamos comiendo. Además se descontrola el mecanismo del hambre. Hay que tener horarios y el hambre volverá. Si se come mientras se ve tele se desconecta el mecanismo de la saciedad, y no sabemos cuándo dejar de comer.
Hay una dieta que siguen algunos artistas (dieta de la zona) que es 40% carbohidratos, 30% proteínas y 30% grasa. El problema es que una dieta normal solo debe incluir 15% de proteínas y comiendo 30% de proteínas se come más grasa saturada. Además todo depende del % de grasa corporal y la actividad física. A una señora le vendieron en su casa un polvo para adelgazar y terminó en el hospital con problemas cardíacos.
QUIERE DIVERTIRSE? VEA CHISTES MEDICOS AQUI: http://tipsparalamujer.googlepages.c
EFECTO MOZART: POR QUE ES IMPORTANTE ESCUCHAR A
MOZART:
Pero, por qué Mozart ?
Porque Mozart tuvo una vida prenatal excepcional. Su madre, que vivió un embarazo feliz, impregnado de música y del amor de su marido - talentoso compositor -, le pudo transmitir al feto el deseo de nacer, de vivir y de comunicar con la misma fuerza que lo deseaba. Wolfang gozó de un entorno familiar y musical formidable, que le permitió codificar su sistema nervioso sobre ritmos fisiológicos verdaderos, universales, cósmicos, dice Tomatis. Esto le permitió ajustar su instrumento corporal a las modulaciones sentidas durante este periodo y su ritmo seguirá siendo el mismo aun cuando comience a hablar, a crear, a componer desde los cinco años hasta su muerte.
Tomado de http://www.geocities.com/gladys001/musi ca.htm
Can Mozart treat heart disease?
Listening to Mozart can reduce stress, boost intelligence and treat heart disease. Doctors could soon be prescribing his music for epilepsy too, says Roger Dobson
Lea el artículo completo en http://gladys.pineda.googlepages.com/ef ectomozart
MOZART:
Pero, por qué Mozart ?
Porque Mozart tuvo una vida prenatal excepcional. Su madre, que vivió un embarazo feliz, impregnado de música y del amor de su marido - talentoso compositor -, le pudo transmitir al feto el deseo de nacer, de vivir y de comunicar con la misma fuerza que lo deseaba. Wolfang gozó de un entorno familiar y musical formidable, que le permitió codificar su sistema nervioso sobre ritmos fisiológicos verdaderos, universales, cósmicos, dice Tomatis. Esto le permitió ajustar su instrumento corporal a las modulaciones sentidas durante este periodo y su ritmo seguirá siendo el mismo aun cuando comience a hablar, a crear, a componer desde los cinco años hasta su muerte.
Tomado de http://www.geocities.com/gladys001/musi
Can Mozart treat heart disease?
Listening to Mozart can reduce stress, boost intelligence and treat heart disease. Doctors could soon be prescribing his music for epilepsy too, says Roger Dobson
Lea el artículo completo en http://gladys.pineda.googlepages.com/ef
EFECTO MOZART: POR QUE ES IMPORTANTE ESCUCHAR A
MOZART:
Pero, por qué Mozart ?
Porque Mozart tuvo una vida prenatal excepcional. Su madre, que vivió un embarazo feliz, impregnado de música y del amor de su marido - talentoso compositor -, le pudo transmitir al feto el deseo de nacer, de vivir y de comunicar con la misma fuerza que lo deseaba. Wolfang gozó de un entorno familiar y musical formidable, que le permitió codificar su sistema nervioso sobre ritmos fisiológicos verdaderos, universales, cósmicos, dice Tomatis. Esto le permitió ajustar su instrumento corporal a las modulaciones sentidas durante este periodo y su ritmo seguirá siendo el mismo aun cuando comience a hablar, a crear, a componer desde los cinco años hasta su muerte.
Tomado de http://www.geocities.com/gladys001/music a.htm
Can Mozart treat heart disease?
Listening to Mozart can reduce stress, boost intelligence and treat heart disease. Doctors could soon be prescribing his music for epilepsy too, says Roger Dobson
Lea el artículo completo en http://gladys.pineda.googlepages.com/efe ctomozart
1/1 An explosion of new research is vastly changing scientists’ understanding of diabetes and giving new clues about how to attack it.
Life Sciences Institute/ University of Michigan
Study Fat tissue from a mouse that was fed a high-fat diet.
The fifth leading killer of Americans, with 73,000 deaths a year, diabetes is a disease in which the body’s failure to regulate glucose, or blood sugar, can lead to serious and even fatal complications. Until very recently, the regulation of glucose — how much sugar is present in a person’s blood, how much is taken up by cells for fuel, and how much is released from energy stores — was regarded as a conversation between a few key players: the pancreas, the liver, muscle and fat.
Now, however, the party is proving to be much louder and more complex than anyone had shown before.
New research suggests that a hormone from the skeleton, of all places, may influence how the body handles sugar. Mounting evidence also demonstrates that signals from the immune system, the brain and the gut play critical roles in controlling glucose and lipid metabolism. (The findings are mainly relevant to Type 2 diabetes, the more common kind, which comes on in adulthood.)
Focusing on the cross-talk between more different organs, cells and molecules represents a “very important change in our paradigm” for understanding how the body handles glucose, said Dr. C. Ronald Kahn, a diabetes researcher and professor at Harvard Medical School.
The defining feature of diabetes is elevated blood sugar. But the reasons for abnormal sugar seem to “differ tremendously from person to person,” said Dr. Robert A. Rizza, a professor at the Mayo Clinic College of Medicine. Understanding exactly what signals are involved, he said, raises the hope of “providing the right care for each person each day, rather than giving everyone the same drug.”
Last summer, researchers at Columbia University Medical Center published startling results showing that a hormone released from bone may help regulate blood glucose.
When the lead researcher, Dr. Gerard Karsenty, first described the findings at a conference, the assembled scientists “were overwhelmed by the potential implications,” said Dr. Saul Malozowski, senior adviser for endocrine physiology research at the National Institute of Diabetes and Digestive and Kidney Diseases, who was not involved in the research. “It was coming from left field. People thought, ‘Oof, this is really new.’
“For the first time,” he went on, “we see that the skeleton is actually an endocrine organ,” producing hormones that act outside of bone.
In previous work, Dr. Karsenty had shown that leptin, a hormone produced by fat, is an important regulator of bone metabolism. In this work, he tested the idea that the conversation was a two-way street. “We hypothesized that if fat regulates bone, bone in essence must regulate fat,” he said.
Working with mice, he found that a previously known substance called osteocalcin, which is produced by bone, acted by signaling fat cells as well as the pancreas. The net effect is to improve how mice secrete and handle insulin, the hormone that helps the body move glucose from the bloodstream into cells of the muscle and liver, where it can be used for energy or stored for future use. Insulin is also important in regulating lipids.
In Type 2 diabetes, patients’ bodies no longer heed the hormone’s directives. Their cells are insulin-resistant, and blood glucose levels surge. Eventually, production of insulin in the pancreas declines as well.
Dr. Karsenty found that in mice prone to Type 2 diabetes, an increase in osteocalcin addressed the twin problems of insulin resistance and low insulin production. That is, it made the mice more sensitive to insulin and it increased their insulin production, thus bringing their blood sugar down. As a bonus, it also made obese mice less fat.
If osteocalcin works similarly in humans, it could turn out to be a “unique new treatment” for Type 2 diabetes, Dr. Malozowski said. (Most current diabetes drugs either raise insulin production or improve insulin sensitivity, but not both. Drugs that increase production tend to make insulin resistance worse.)
A deficiency in osteocalcin could also turn out to be a cause of Type 2 diabetes, Dr. Karsenty said. Another recent suspect in glucose regulation is the immune system. In 2003, researchers from two laboratories found that fat tissue from obese mice contained an abnormally large number of macrophages, immune cells that contribute to inflammation. The finding piqued the curiosity of researchers. “I remember reading the paper and thinking: ‘Wow, look at all those macrophages. What are they doing?’” said Dr. Jerrold M. Olefsky of the University of California, San Diego, School of Medicine.
Scientists have long suspected that inflammation was somehow related to insulin resistance, which precedes nearly all cases of Type 2 diabetes. In the early 1900s, diabetics were sometimes given high doses of aspirin, which is an anti-inflammatory, Dr. Olefsky said.
Only in the past few years has research into the relationship of obesity, inflammation and insulin resistance become “really hot,” said Dr. Alan R. Saltiel, director of the Life Sciences Institute at the University of Michigan.
2/2 Many researchers agree that obesity is accompanied by a state of chronic, low-grade inflammation in which some immune cells are activated, and that that may be a primary cause of insulin resistance. They also agree that the main type of cell responsible for the inflammation is the macrophage, Dr. Saltiel said.
Skip to next paragraph
Health Guide
Type 2 Diabetes Multimedia
Graphic
The Body’s Role in Diabetes But major questions remain, he said: “Why are these macrophages attracted to fat, liver and muscle in the first place? What are they doing? What are they secreting? What other immune cells are in there?”
New research also suggests that “not all macrophages are created equal,” added Dr. Saltiel. There appear to be “good ones and bad ones” competing in fat tissue, with potentially large consequences for inflammation and diabetes.
Meanwhile, the promise of anti-inflammatory compounds as treatment continues to attract attention. “Certain cellular anti-inflammatory proteins may now be important new targets for drug discovery for diabetes treatment,” Dr. Olefsky said. But damping down the immune system is also potentially risky, he noted, adding: “If you’re inhibiting the macrophage inflammatory pathway, that’s good for insulin resistance and diabetes. But it might not be so good for your susceptibility to infections.” A major goal is to develop a drug that quashes only the specific component of macrophage inflammation that leads to insulin resistance, without causing other side effects.
One class of current medications, called thiazolidinediones, may work in part by reducing inflammation, which may in turn improve insulin sensitivity. But an example from this class, the drug Avandia, was also found to increase the risk of heart attacks.
Another participant in the glucose conversation is the brain. Its role has long been suspected. More than a century ago, the French physiologist Claude Bernard suggested that the brain was important in blood sugar regulation. He punctured the brains of experimental animals in specific areas and managed to derange their blood sugar metabolism, making them diabetic.
But for years, virtually no one followed up on this finding, said Dr. Kahn, of Harvard.
People thought about glucose as a critical fuel for the brain, Dr. Kahn said, but did not explore the brain’s role in glucose regulation.
Only recently, with more advanced laboratory techniques, has this role been definitively established and expanded upon.
Today’s genetic techniques, said Dr. Rizza, at the Mayo Clinic, are what have “really driven the process.”
For instance, once scientists developed the ability to manipulate mice so that they lacked particular receptors in specific tissues, they could show that mice without insulin receptors in the brain could not regulate glucose properly and went on to develop diabetes, said Dr. Kahn, whose laboratory published this groundbreaking work in 2000.
Other researchers have shown that free fatty acids, as well as the hormone leptin, produced by fat tissue, signal directly to a part of the brain called the hypothalamus, which also regulates appetite, temperature and sex drive.
And several recent papers suggest that direct signaling by glucose itself to neurons in the hypothalamus is also crucial to normal blood sugar regulation in mice.
“If the brain is getting the message that you have adequate amounts of these hormones and nutrients, it will constrain glucose production by the liver and keep blood glucose relatively low,” said Dr. Michael W. Schwartz, a professor at the University of Washington. But if the brain senses inadequate amounts, he continued, it will “activate responses that cause the liver to make more glucose, and new evidence suggests that this contributes to diabetes and impaired glucose metabolism.”
The brain, therefore, appears to be listening to — and weighing and making sense of — a chorus of signals from insulin, leptin, free fatty acids and glucose itself. In response, it appears to send signals to liver and muscle cells by way of several nerves, though additional mechanisms are probably involved. The gut also seems to chime in, said Dr. Rizza, adding that for him, this aspect of sugar regulation came as “the biggest gee whiz of all.”
“Food comes in through the gut, so of course you should look there” for molecules involved in glucose regulation, he said. “But few people realized this until very recently.”
Hormones from the small intestine called incretins turn out to talk directly with the brain and pancreas in ways that help reduce blood sugar and cause animals and people to eat less and lose weight, Dr. Rizza said.
Numerous molecules that mimic incretins or prevent them from being degraded are in clinical trials. Two such drugs have been approved by the Food and Drug Administration: Byetta, an incretin mimic, from Amylin Pharmaceuticals and Eli Lilly; and Januvia, from Merck, which inhibits the destruction of the incretin GLP1. (Dr. Rizza is an adviser to Merck but says all consulting fees go to the Mayo Clinic for education and research.)
Still, it can be hard to predict how different drugs will interact in the body. And many promising candidates will turn out to have side effects — chattering helpfully with one organ, but problematically with another.
“The picture is becoming more and more complicated,” Dr. Saltiel said. “And let’s face it, it was pretty complicated before.”
Taked from the New York Times http://www.nytimes.com/2007/10/16/healt h/16diab.html?pagewanted=2&_r=1
Life Sciences Institute/ University of Michigan
Study Fat tissue from a mouse that was fed a high-fat diet.
The fifth leading killer of Americans, with 73,000 deaths a year, diabetes is a disease in which the body’s failure to regulate glucose, or blood sugar, can lead to serious and even fatal complications. Until very recently, the regulation of glucose — how much sugar is present in a person’s blood, how much is taken up by cells for fuel, and how much is released from energy stores — was regarded as a conversation between a few key players: the pancreas, the liver, muscle and fat.
Now, however, the party is proving to be much louder and more complex than anyone had shown before.
New research suggests that a hormone from the skeleton, of all places, may influence how the body handles sugar. Mounting evidence also demonstrates that signals from the immune system, the brain and the gut play critical roles in controlling glucose and lipid metabolism. (The findings are mainly relevant to Type 2 diabetes, the more common kind, which comes on in adulthood.)
Focusing on the cross-talk between more different organs, cells and molecules represents a “very important change in our paradigm” for understanding how the body handles glucose, said Dr. C. Ronald Kahn, a diabetes researcher and professor at Harvard Medical School.
The defining feature of diabetes is elevated blood sugar. But the reasons for abnormal sugar seem to “differ tremendously from person to person,” said Dr. Robert A. Rizza, a professor at the Mayo Clinic College of Medicine. Understanding exactly what signals are involved, he said, raises the hope of “providing the right care for each person each day, rather than giving everyone the same drug.”
Last summer, researchers at Columbia University Medical Center published startling results showing that a hormone released from bone may help regulate blood glucose.
When the lead researcher, Dr. Gerard Karsenty, first described the findings at a conference, the assembled scientists “were overwhelmed by the potential implications,” said Dr. Saul Malozowski, senior adviser for endocrine physiology research at the National Institute of Diabetes and Digestive and Kidney Diseases, who was not involved in the research. “It was coming from left field. People thought, ‘Oof, this is really new.’
“For the first time,” he went on, “we see that the skeleton is actually an endocrine organ,” producing hormones that act outside of bone.
In previous work, Dr. Karsenty had shown that leptin, a hormone produced by fat, is an important regulator of bone metabolism. In this work, he tested the idea that the conversation was a two-way street. “We hypothesized that if fat regulates bone, bone in essence must regulate fat,” he said.
Working with mice, he found that a previously known substance called osteocalcin, which is produced by bone, acted by signaling fat cells as well as the pancreas. The net effect is to improve how mice secrete and handle insulin, the hormone that helps the body move glucose from the bloodstream into cells of the muscle and liver, where it can be used for energy or stored for future use. Insulin is also important in regulating lipids.
In Type 2 diabetes, patients’ bodies no longer heed the hormone’s directives. Their cells are insulin-resistant, and blood glucose levels surge. Eventually, production of insulin in the pancreas declines as well.
Dr. Karsenty found that in mice prone to Type 2 diabetes, an increase in osteocalcin addressed the twin problems of insulin resistance and low insulin production. That is, it made the mice more sensitive to insulin and it increased their insulin production, thus bringing their blood sugar down. As a bonus, it also made obese mice less fat.
If osteocalcin works similarly in humans, it could turn out to be a “unique new treatment” for Type 2 diabetes, Dr. Malozowski said. (Most current diabetes drugs either raise insulin production or improve insulin sensitivity, but not both. Drugs that increase production tend to make insulin resistance worse.)
A deficiency in osteocalcin could also turn out to be a cause of Type 2 diabetes, Dr. Karsenty said. Another recent suspect in glucose regulation is the immune system. In 2003, researchers from two laboratories found that fat tissue from obese mice contained an abnormally large number of macrophages, immune cells that contribute to inflammation. The finding piqued the curiosity of researchers. “I remember reading the paper and thinking: ‘Wow, look at all those macrophages. What are they doing?’” said Dr. Jerrold M. Olefsky of the University of California, San Diego, School of Medicine.
Scientists have long suspected that inflammation was somehow related to insulin resistance, which precedes nearly all cases of Type 2 diabetes. In the early 1900s, diabetics were sometimes given high doses of aspirin, which is an anti-inflammatory, Dr. Olefsky said.
Only in the past few years has research into the relationship of obesity, inflammation and insulin resistance become “really hot,” said Dr. Alan R. Saltiel, director of the Life Sciences Institute at the University of Michigan.
2/2 Many researchers agree that obesity is accompanied by a state of chronic, low-grade inflammation in which some immune cells are activated, and that that may be a primary cause of insulin resistance. They also agree that the main type of cell responsible for the inflammation is the macrophage, Dr. Saltiel said.
Skip to next paragraph
Health Guide
Type 2 Diabetes Multimedia
Graphic
The Body’s Role in Diabetes But major questions remain, he said: “Why are these macrophages attracted to fat, liver and muscle in the first place? What are they doing? What are they secreting? What other immune cells are in there?”
New research also suggests that “not all macrophages are created equal,” added Dr. Saltiel. There appear to be “good ones and bad ones” competing in fat tissue, with potentially large consequences for inflammation and diabetes.
Meanwhile, the promise of anti-inflammatory compounds as treatment continues to attract attention. “Certain cellular anti-inflammatory proteins may now be important new targets for drug discovery for diabetes treatment,” Dr. Olefsky said. But damping down the immune system is also potentially risky, he noted, adding: “If you’re inhibiting the macrophage inflammatory pathway, that’s good for insulin resistance and diabetes. But it might not be so good for your susceptibility to infections.” A major goal is to develop a drug that quashes only the specific component of macrophage inflammation that leads to insulin resistance, without causing other side effects.
One class of current medications, called thiazolidinediones, may work in part by reducing inflammation, which may in turn improve insulin sensitivity. But an example from this class, the drug Avandia, was also found to increase the risk of heart attacks.
Another participant in the glucose conversation is the brain. Its role has long been suspected. More than a century ago, the French physiologist Claude Bernard suggested that the brain was important in blood sugar regulation. He punctured the brains of experimental animals in specific areas and managed to derange their blood sugar metabolism, making them diabetic.
But for years, virtually no one followed up on this finding, said Dr. Kahn, of Harvard.
People thought about glucose as a critical fuel for the brain, Dr. Kahn said, but did not explore the brain’s role in glucose regulation.
Only recently, with more advanced laboratory techniques, has this role been definitively established and expanded upon.
Today’s genetic techniques, said Dr. Rizza, at the Mayo Clinic, are what have “really driven the process.”
For instance, once scientists developed the ability to manipulate mice so that they lacked particular receptors in specific tissues, they could show that mice without insulin receptors in the brain could not regulate glucose properly and went on to develop diabetes, said Dr. Kahn, whose laboratory published this groundbreaking work in 2000.
Other researchers have shown that free fatty acids, as well as the hormone leptin, produced by fat tissue, signal directly to a part of the brain called the hypothalamus, which also regulates appetite, temperature and sex drive.
And several recent papers suggest that direct signaling by glucose itself to neurons in the hypothalamus is also crucial to normal blood sugar regulation in mice.
“If the brain is getting the message that you have adequate amounts of these hormones and nutrients, it will constrain glucose production by the liver and keep blood glucose relatively low,” said Dr. Michael W. Schwartz, a professor at the University of Washington. But if the brain senses inadequate amounts, he continued, it will “activate responses that cause the liver to make more glucose, and new evidence suggests that this contributes to diabetes and impaired glucose metabolism.”
The brain, therefore, appears to be listening to — and weighing and making sense of — a chorus of signals from insulin, leptin, free fatty acids and glucose itself. In response, it appears to send signals to liver and muscle cells by way of several nerves, though additional mechanisms are probably involved. The gut also seems to chime in, said Dr. Rizza, adding that for him, this aspect of sugar regulation came as “the biggest gee whiz of all.”
“Food comes in through the gut, so of course you should look there” for molecules involved in glucose regulation, he said. “But few people realized this until very recently.”
Hormones from the small intestine called incretins turn out to talk directly with the brain and pancreas in ways that help reduce blood sugar and cause animals and people to eat less and lose weight, Dr. Rizza said.
Numerous molecules that mimic incretins or prevent them from being degraded are in clinical trials. Two such drugs have been approved by the Food and Drug Administration: Byetta, an incretin mimic, from Amylin Pharmaceuticals and Eli Lilly; and Januvia, from Merck, which inhibits the destruction of the incretin GLP1. (Dr. Rizza is an adviser to Merck but says all consulting fees go to the Mayo Clinic for education and research.)
Still, it can be hard to predict how different drugs will interact in the body. And many promising candidates will turn out to have side effects — chattering helpfully with one organ, but problematically with another.
“The picture is becoming more and more complicated,” Dr. Saltiel said. “And let’s face it, it was pretty complicated before.”
Taked from the New York Times http://www.nytimes.com/2007/10/16/healt
Grandes colonias de abejas sucumben en Alemania ante la acción de insecticidas y pesticidas. Las pérdidas del sector apícola se incrementan, y algunos países latinoamericanos salen beneficiados.
Las abejas son parte fundamental en la cadena alimentaria de la naturaleza. La revista británica Science calcula que una tercera parte de los alimentos que consume el ser humano está relacionada, de una manera u otra, con la labor que las abejas realizan al polinizar las plantas de las cuales habrán de surgir frutas y verduras.
Bildunterschrift: Großansicht des Bildes mit der Bildunterschrift: La polinización es esencial para la cadena alimentaria.
"Una bomba de tiempo"
Si ir más lejos, las olivas y los cerezos dependen exclusivamente de que las abejas cumplan con esta tarea. Pero en Alemania, este importante eslabón de la cadena ecológica se rompe a niveles que algunos productores agrícolas consideran alarmantes.
"Lo que aquí tenemos es una auténtica bomba de tiempo", afirma al diario Die Welt el apicultor Hubert Fischer, de Baden-Württemberg. A finales del invierno pasado, Fischer vio cómo aparecieron miles de abejas muertas frente a sus colmenas. Según él, esto se debe a los efectos de un poderoso insecticida que flota en el aire de esa región germana.
La sustancia es utilizada por agricultores para proteger sus sembradíos de maíz. Pero, según reporte el diario berlinés, los usuarios han hecho abuso del producto, de tal modo que ahora es capaz de matar a colonias enteras de abejas en poco tiempo.
Calculan grandes pérdidas
Las consecuencias ya se dejan notar. En Alemania hay cerca de 4.500 empresas dedicadas a la elaboración de cera y miel, a partir de la apicultura. A ello se suman 80.000 personas que ejercen la crianza de abejas como afición.
De acuerdo con Die Welt, la industria se enfrenta a grandes pérdidas debido a la muerte de colonias de abejas por el uso de pesticidas. Se incrementaría así la dependencia que Alemania, con su modesta producción de derivados apícolas, presenta en cuanto al consumo de miel.
Bildunterschrift: Großansicht des Bildes mit der Bildunterschrift: En Alemania hay miles de apicultores aficionados.
Los beneficiados son algunos países latinoamericanos. Argentina exportó a Alemania 29.297 toneladas de miel de abeja en 2007, según un informe acerca del comercio mundial con este producto. Le siguen México, con 14.453 toneladas; Uruguay, con 9.589 y Chile, con 5.564 toneladas.
Los alemanes aman la miel
Puede decirse que Alemania depende de las importaciones para cubrir la demanda de miel. El consumo anual es ubicado en 90.000 toneladas, de las cuales solamente 20.000 son producidas en tierras germanas. La cuota total de importación anual es de 94.075 toneladas anuales.
Cada alemán consume en promedio 1,4 kilos de miel por año. Es el mayor nivel de consumo de miel en el mundo. No obstante el discreto volumen que maneja, la industria apícola alemana ve en el auge de insecticidas y pesticidas una amenaza.
Bildunterschrift: Großansicht des Bildes mit der Bildunterschrift: Colonias de abejas, en auge en América Latina.
Los apicultores alemanes culpan a las empresas fabricantes de pesticidas por la muerte masiva de abejas. Los inculpados se defienden, argumentando que si tantas abejas mueren es porque los agricultores hacen caso omiso de las indicaciones ara cada producto.
No obstante, se ha acordado el pago de algunas indemnizaciones por la pérdida de grandes colonias de abejas. Según reporta Die Welt, los fondos podrían comenzar a otorgarse a apicultores afectados a partir de julio próximo. Algunos de los productos señalados como causantes de la muerte masiva de abejas, entre tanto, también han sido prohibidos.
Tomado de: http://www.dw-world.de/dw/article/0,,34 24954,00.html?maca=spa-Titulares-640-htm l
Interested in cholesterol? Read this overview: http://health.nytimes.com/health/gu ides/nutrition/cholesterol/overview.html
Las abejas son parte fundamental en la cadena alimentaria de la naturaleza. La revista británica Science calcula que una tercera parte de los alimentos que consume el ser humano está relacionada, de una manera u otra, con la labor que las abejas realizan al polinizar las plantas de las cuales habrán de surgir frutas y verduras.
Bildunterschrift: Großansicht des Bildes mit der Bildunterschrift: La polinización es esencial para la cadena alimentaria.
"Una bomba de tiempo"
Si ir más lejos, las olivas y los cerezos dependen exclusivamente de que las abejas cumplan con esta tarea. Pero en Alemania, este importante eslabón de la cadena ecológica se rompe a niveles que algunos productores agrícolas consideran alarmantes.
"Lo que aquí tenemos es una auténtica bomba de tiempo", afirma al diario Die Welt el apicultor Hubert Fischer, de Baden-Württemberg. A finales del invierno pasado, Fischer vio cómo aparecieron miles de abejas muertas frente a sus colmenas. Según él, esto se debe a los efectos de un poderoso insecticida que flota en el aire de esa región germana.
La sustancia es utilizada por agricultores para proteger sus sembradíos de maíz. Pero, según reporte el diario berlinés, los usuarios han hecho abuso del producto, de tal modo que ahora es capaz de matar a colonias enteras de abejas en poco tiempo.
Calculan grandes pérdidas
Las consecuencias ya se dejan notar. En Alemania hay cerca de 4.500 empresas dedicadas a la elaboración de cera y miel, a partir de la apicultura. A ello se suman 80.000 personas que ejercen la crianza de abejas como afición.
De acuerdo con Die Welt, la industria se enfrenta a grandes pérdidas debido a la muerte de colonias de abejas por el uso de pesticidas. Se incrementaría así la dependencia que Alemania, con su modesta producción de derivados apícolas, presenta en cuanto al consumo de miel.
Bildunterschrift: Großansicht des Bildes mit der Bildunterschrift: En Alemania hay miles de apicultores aficionados.
Los beneficiados son algunos países latinoamericanos. Argentina exportó a Alemania 29.297 toneladas de miel de abeja en 2007, según un informe acerca del comercio mundial con este producto. Le siguen México, con 14.453 toneladas; Uruguay, con 9.589 y Chile, con 5.564 toneladas.
Los alemanes aman la miel
Puede decirse que Alemania depende de las importaciones para cubrir la demanda de miel. El consumo anual es ubicado en 90.000 toneladas, de las cuales solamente 20.000 son producidas en tierras germanas. La cuota total de importación anual es de 94.075 toneladas anuales.
Cada alemán consume en promedio 1,4 kilos de miel por año. Es el mayor nivel de consumo de miel en el mundo. No obstante el discreto volumen que maneja, la industria apícola alemana ve en el auge de insecticidas y pesticidas una amenaza.
Bildunterschrift: Großansicht des Bildes mit der Bildunterschrift: Colonias de abejas, en auge en América Latina.
Los apicultores alemanes culpan a las empresas fabricantes de pesticidas por la muerte masiva de abejas. Los inculpados se defienden, argumentando que si tantas abejas mueren es porque los agricultores hacen caso omiso de las indicaciones ara cada producto.
No obstante, se ha acordado el pago de algunas indemnizaciones por la pérdida de grandes colonias de abejas. Según reporta Die Welt, los fondos podrían comenzar a otorgarse a apicultores afectados a partir de julio próximo. Algunos de los productos señalados como causantes de la muerte masiva de abejas, entre tanto, también han sido prohibidos.
Tomado de: http://www.dw-world.de/dw/article/0,,34
Interested in cholesterol? Read this overview: http://health.nytimes.com/health/gu

How to Cure Puffy Eyes
from wikiHow - The How to Manual That You Can Edit
Disgusted with the bags around your eyes? Not a fan of cosmetic surgery? If you can be satisfied with looking a lot better, as opposed to surgical perfection, there are several ways to approach reducing the puffiness under your eyes without going under the knife.
Steps
- Reduce swelling directly. Eye puffiness is a type of fluid build-up (edema) in the tissues around your eyes, called the orbits. Therefore, the steps taken to reduce puffiness are similar to those taken to reduce any kind of swelling. The following are "quick fixes" to temporarily encourage fluid to drain away from under your eyes.
- Place cold cucumber slices on your eyes. It is the cold temperature that is helping rather than the product itself. The aroma, however, can be soothing and relaxing. Slice them into 1/8" discs and let them float in cool tap water for a few minutes. Shake them off well before applying to your eyes.
- Use cold, refrigerated used tea bags. Like the cucumber slices, the coolness reduces circulation, but the tea actually has a slightly astringent (tissue-shrinking) effect as well.
- For a less messy alternative, try putting 2 metal tablespoons in the fridge and use them daily by placing the backs against your eyes.
- Rinse your face in cool water and pat dry.
- Strange as it sounds, hemorrhoid cream, which is meant to reduce swelling, may work well.
- Place cold cucumber slices on your eyes. It is the cold temperature that is helping rather than the product itself. The aroma, however, can be soothing and relaxing. Slice them into 1/8" discs and let them float in cool tap water for a few minutes. Shake them off well before applying to your eyes.
- Get enough sleep. If you have puffy eyes all day, it could be that you're simply not getting enough sleep, or the quality of the sleep you are getting is poor. Puffiness under the eyes is a common symptom of sleep deprivation.
- Elevate your head when you sleep. It's not unusual to have puffy eyes upon waking. A possible explanation for this may be that when you are laying down for several hours in a horizontal position and then stand up, the fluid that was resting under your eyes is suddenly being pulled down by gravity.[1] This swelling, however, should subside shortly. To reduce it, you can try elevating your head while sleeping so that the fluid is not as drastically drawn down when you get up.
- Cure puffy eyes from the inside out. Puffiness is a manifestation of excess fluid retention. By addressing your body's tendency to tuck fluid away, you may be able to indirectly reduce swelling around your eyes.
- Reduce your salt intake. A high intake of sodium may be causing you to retain more fluid, in which case reducing the salt in your diet may produce good results (not only for your eyes, but also for your health in general).
- Snack on bananas and raisins, both of which alleviate fluid retention.[2]
- Consume cabbage or cranberry juice. Both are diuretics, which will help you "evacuate" some excess fluid.[2] Don't turn to caffeine as your diuretic of choice, as it can interfere with sleep and bring back the puffiness.
- Exercise to improve circulation, which will help your body move fluid through your body, rather than letting it accumulate.
- Reduce your salt intake. A high intake of sodium may be causing you to retain more fluid, in which case reducing the salt in your diet may produce good results (not only for your eyes, but also for your health in general).
- Determine if you have any of the conditions associated with puffy eyes. Sometimes the swelling is a side effect of another condition, which is temporary, or must be treated individually.
- pregnancy - commonly associated with fluid retention
- hormonal variation in the menstrual cycle - commonly associated with fluid retention
- dermatitis - sensitive skin is more likely to swell in response to irritants
- allergies - can cause leaks in the subcutaneous capillary beds around the eyes[3]
- mononucleosis - puffy eyes may be an early symptom of infection
- medication - puffiness or water retention could be a side effect
- more serious medical conditions - see Warnings below
- pregnancy - commonly associated with fluid retention
- Accept yourself. If you've checked with your doctor, then your puffy eyes are probably only a cosmetic issue. It happens with age, and sometimes it just happens. Learn to draw attention to other features that haven't aged, such as the color of your eyes, the curl in your hair, or your attitude towards life.
Tips
- You may notice that puffiness is worse in hot weather--The body is less efficient at removing fluid from tissues when it's warmer.[4]
- Alcohol and tobacco use can cause puffy eyes indirectly by affecting your sleep and hormonal cycles (among other things).
Warnings
- If the swelling is extreme and/or persistent, it may be a symptom of a serious illness, such as a blood clot, thyroid disease, or renal failure.[5] Check with a doctor to investigate if the puffiness won't go away.
- Be careful about what type of tea you use. If you have allergies, an herbal tea like chamomile might swell your eyes.
- Do not apply ice or extremely cold water directly to the skin around the eyes for more than a couple of seconds.
- Exercise caution when using a new cosmetic product or trying a home remedy. If the condition worsens, or if you exhibit other symptoms, discontinue use immediately and contact your primary care physician or dermatologist for severe or persisting symptoms.
Related wikiHows
- How to Get Rid of Black Circles Under Your Eyes
- How to Cure or Alleviate Edema
- How to Prevent Varicose Veins
- How to Sleep Better
- How to Make Your Own Beauty Products
- How to Become a Natural Beauty
- How to Improve Your Beauty Sleep
Sources and Citations
- ↑ http://en.wikipedia.org/wiki/Eye_puffine
ss - ↑ 2.0 2.1 http://health.howstuffworks.com/home-rem
edies-for-water-retention.htm - ↑ http://en.wikipedia.org/wiki/Eye_puffine
ss - ↑ http://www.betterhealth.vic.gov.au/bhcv2/b
hcArticles.nsf/pages/Fluid_retention?Ope nDocument - ↑ http://www.wrongdiagnosis.com/sym/perior
bital_oedema.htm#intro
Article provided by wikiHow, a collaborative writing project to build the world's largest, highest quality how-to manual. Please edit this article and find author credits at the original wikiHow article on How to Cure Puffy Eyes. All content on wikiHow can be shared under a Creative Commons license.
